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However, further clinical studies are essential to substantiate these potential benefits

Noteworthy, pharmacological induction of HO-1 has been reported to elicit neuroprotective effects against the neurotoxic A-protein aggregates (Wang et al., 2016) and hamper the replication of HSV in a human neuronal cell line, although this was determined using HSV-2 (Ibez et al., 2017)

this data may suggest an increased efficacy of anti-PD-1 antibodies in combination with manganese intake, as preliminarily assessed in a phase I study (NCT03991559) (396)

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